Laboratory testing for platelet function disorders

Platelet Function Disorders in Adolescents with Heavy Menstrual Bleeding: Clinical Presentations, Laboratory Testing and Treatment Options

Heavy menstrual bleeding (HMB) is a common problem in adolescent girls where it comprises a significant public health problem [1]. HMB affects almost one-third of adolescent girls at the time of the menarche. Reports from multiple studies indicate that between 5 and 10 percent of young girls in this age group will seek medical treatment and of those, approximately one-half will experience surgi...

Clinical and Laboratory Diagnosis of Inherited Platelet Function Disorders.

In the present issue of TRANSFUSION MEDICINE AND HEMOTHERAPY current strategies for the diagnosis of inherited platelet function disorders that have been established in different clinics in the German-speaking countries are summarized. These strategies are partially related to diagnostic algorithms applied in Italy or the UK [1, 2]. Inherited platelet function disorders represent a heterogeneou...

Laboratory analyses for evaluation of platelet disorders and platelet concentrates

Platelet function disorders.

Platelet function defects comprise a large and heterogeneous group of bleeding disorders that range in severity from mild to severe. Patients may be asymptomatic; however, the majority who are diagnosed present with easy bruising and mucocutaneous bleeding, or with excessive haemorrhage following injury or surgery. As the complex internal biochemical and signal transduction pathways are further...

Disorders of platelet function.

Careful study of the hereditary defects of platelet function, like that of the congenital coagulation disorders, has made a large contribution to our understanding of the normal haemostatic mechanism. I should like today to discuss the evolution of knowledge about this uncommon group of disorders to indicate how they help to advance our understanding of normal platelet physiology, and to point ...